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Hassall's Corpuscles

Discover the fascinating role and importance of Hassall's corpuscles in the human thymus gland, shedding light on their function within the immune system.

Hassall's Corpuscles


Hassall's corpuscles, also known as thymic corpuscles or thymic medullary epithelial cells, are unique structures found in the thymus gland. These structures were first described by Arthur Hill Hassall in 1849 and are named after him. Understanding the significance and characteristics of Hassall's corpuscles is essential for medical professionals, particularly those preparing for the United States Medical Licensing Examination (USMLE). This guide aims to provide a comprehensive overview of Hassall's corpuscles, their function, development, and clinical importance.

Anatomy and Location

Hassall's corpuscles are small, spherical structures found within the medulla of the thymus gland. The thymus gland itself is located in the anterior mediastinum, behind the sternum and in front of the heart. It is a bilobed organ that undergoes involution with age.

Structure and Development

Hassall's corpuscles are composed of concentric layers of flattened epithelial cells, forming a whorled or onion-like appearance. These cells are derived from the endodermal layer of the pharyngeal pouches during embryonic development. As the thymus gland matures, these cells differentiate into various types of thymic medullary epithelial cells, including the Hassall's corpuscles.


The exact function of Hassall's corpuscles is not yet fully understood, but several theories have been proposed. It is believed that these structures play a vital role in the maturation and selection of T lymphocytes, which are crucial for immune function. They may also be involved in the production of cytokines and other regulatory molecules. Hassall's corpuscles have been observed to increase in number with age, suggesting a possible role in immune senescence.

Clinical Significance

The presence and morphology of Hassall's corpuscles can provide valuable diagnostic information. They are considered a histological hallmark of the thymus gland and can aid in distinguishing thymic tissue from other mediastinal masses. Additionally, abnormalities in the development or appearance of Hassall's corpuscles may be indicative of certain thymic disorders, such as thymoma or thymic hyperplasia.

USMLE Relevance

Knowledge of Hassall's corpuscles is relevant to various disciplines within the USMLE curriculum, including anatomy, histology, and pathology. Understanding their location, structure, and function is crucial for accurately interpreting histological slides and making appropriate diagnoses. Questions related to thymus gland disorders, immune system development, and lymphocyte maturation may incorporate the concept of Hassall's corpuscles. Therefore, it is important for USMLE candidates to be familiar with the role and significance of these structures.


Hassall's corpuscles are unique structures found within the medulla of the thymus gland. While their exact function is not fully understood, they are believed to be involved in T lymphocyte maturation and immune regulation. Their presence and morphology can aid in diagnosing thymic disorders and distinguishing thymic tissue from other mediastinal masses. Understanding the anatomy, development, and clinical relevance of Hassall's corpuscles is important for medical professionals preparing for the USMLE.

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