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Prostate Glandular Tissue

Discover the fascinating functions and potential health implications of prostate glandular tissue in this eye-opening article.

USMLE Guide: Prostate Glandular Tissue


This informative USMLE guide aims to provide a comprehensive understanding of prostate glandular tissue. The article will cover various aspects, including anatomy, histology, function, and clinical significance.


The prostate gland is a walnut-sized, accessory reproductive organ located below the bladder in males. It surrounds the prostatic urethra and is divided into four main regions: anterior, posterior, lateral, and median lobes. The gland is encapsulated by a fibromuscular tissue known as the prostatic capsule.


The prostate glandular tissue is composed of numerous glandular units called prostatic acini. These acini are lined by two types of epithelial cells: secretory columnar epithelial cells and basal cells. The secretory cells produce prostatic fluid, which constitutes a major component of semen. Basal cells act as stem cells, aiding in the regeneration and maintenance of the glandular tissue.


The primary function of prostate glandular tissue is to produce and secrete prostatic fluid. This fluid contains various substances, including citric acid, enzymes, and prostate-specific antigen (PSA). Prostatic fluid helps nourish and protect sperm, enhancing their motility and survival. It also aids in the neutralization of acidic vaginal pH, promoting optimal conditions for fertilization.

Clinical Significance

  1. Benign Prostatic Hyperplasia (BPH): With age, the prostate gland may undergo noncancerous enlargement, leading to BPH. This condition can cause urinary symptoms like increased frequency, weak urinary stream, and difficulty initiating urination.
  2. Prostate Cancer: Prostate glandular tissue is susceptible to cancerous growth. Prostate cancer is a common malignancy in males and may present with symptoms such as urinary obstruction, hematuria, or bone pain if it metastasizes.
  3. Prostatitis: Inflammation of the prostate gland, known as prostatitis, can result from various causes, including infection. Symptoms include pelvic pain, urinary urgency, and discomfort during urination.
  4. Prostate-specific Antigen (PSA): PSA, a protein produced by prostate glandular tissue, is used as a screening test for prostate cancer. Elevated PSA levels may indicate the presence of cancer, although further diagnostic tests are required for confirmation.


Understanding the anatomy, histology, function, and clinical significance of prostate glandular tissue is crucial for medical professionals. This USMLE guide has provided an overview of these aspects, highlighting the importance of the prostate gland in male reproductive health.

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