Sign InSign Up
All Posts

Sjögren's Syndrome

Discover the hidden truths behind Sjögren's Syndrome and how it impacts millions worldwide, unraveling the mysteries surrounding this complex autoimmune disorder.

USMLE Guide: Sjögren's Syndrome


Sjögren's Syndrome is a chronic autoimmune disorder characterized by inflammation and dysfunction of the exocrine glands, primarily affecting the salivary and lacrimal glands. This USMLE guide aims to provide a comprehensive overview of Sjögren's Syndrome, including its clinical presentation, diagnosis, and management.


  • sjögren's syndrome is more common in middle-aged women, with a female to male ratio of approximately 9:1.
  • Prevalence is estimated to be around 0.2-1.0% in the general population.
  • It is often associated with other autoimmune diseases, such as rheumatoid arthritis and systemic lupus erythematosus.

Clinical Presentation

Dryness of the eyes and mouth

  • Patients commonly present with symptoms of dry eyes (xerophthalmia) and dry mouth (xerostomia).
  • Dryness of the eyes can cause a gritty or sandy sensation, redness, blurred vision, and increased sensitivity to light.
  • Dryness of the mouth can lead to difficulty swallowing, altered taste, increased dental caries, and oral infections.

Systemic manifestations

  • Sjögren's Syndrome can also affect other organ systems, resulting in various systemic symptoms:
    • Musculoskeletal: Joint pain, stiffness, and swelling.
    • Pulmonary: Chronic cough, shortness of breath.
    • Renal: Interstitial nephritis, renal tubular acidosis.
    • Hematological: Anemia, lymphoma (increased risk).
    • Neurological: Peripheral neuropathy, cognitive dysfunction.


Clinical evaluation

Laboratory tests

  • Serological testing:
    • Positive anti-SSA (Ro) and/or anti-SSB (La) antibodies.
    • Elevated erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP).
    • Routine blood tests may reveal anemia and elevated immunoglobulin levels.
  • Schirmer's test:
    • Measures tear production using filter paper; decreased wetting suggests dry eyes.
  • Salivary flow rate:
    • Measurement of unstimulated salivary flow; decreased flow indicates dry mouth.


  • Minor salivary gland biopsy:
    • Reveals focal lymphocytic infiltrates with destruction of acinar cells.
    • Lymphocytic foci are a hallmark of Sjögren's Syndrome.


Symptomatic treatment

  • Artificial tears and lubricating eye drops for dry eyes.
  • Frequent sips of water, sugar-free gum, and saliva substitutes for dry mouth.
  • Avoidance of medications that worsen dryness (e.g., anticholinergics).

Disease-modifying treatment

  • Hydroxychloroquine:
    • Often used as a first-line agent.
    • Reduces systemic manifestations and prevents disease progression.
  • Immunosuppressive agents:
    • Methotrexate or azathioprine may be considered for severe cases.
  • B-cell-targeted therapy:
    • Rituximab, a monoclonal antibody, can be used in refractory cases.

Complications and follow-up

  • Increased risk of lymphoma necessitates regular monitoring of lymph nodes and other potential sites.
  • Dental care and oral hygiene should be emphasized to prevent dental caries and infections.
  • Ophthalmology follow-up is crucial to manage potential corneal complications.


Sjögren's Syndrome is a chronic autoimmune disorder primarily affecting the salivary and lacrimal glands, leading to dryness of the eyes and mouth. It often coexists with other autoimmune diseases and can involve multiple organ systems. Diagnosis is based on clinical evaluation, serological testing, and histopathology. Treatment focuses on symptom management and disease modification. Regular monitoring for complications and interdisciplinary management are essential for optimal patient care.

USMLE Test Prep
a StudyNova service


GuidesStep 1 Sample QuestionsStep 2 Sample QuestionsStep 3 Sample QuestionsPricing

Install App coming soon

© 2024 StudyNova, Inc. All rights reserved.