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Migraine Medication Side Effects 1

Migraine medication side effects


Vignette: A 28-year-old woman presents to her primary care physician with complaints of severe headaches. She has a history of migraines, for which she has tried over-the-counter pain relievers with minimal relief. Her physician prescribes a medication that acts as a 5-HT1B/1D receptor agonist. Which of the following is a potential adverse effect of this medication?


A. Tachycardia

B. Hypotension

C. Chest tightness

D. Hyperglycemia

E. Polyuria


C. Chest tightness


The medication prescribed by the physician is likely a triptan, a class of drugs commonly used in the treatment of migraines. Triptans, such as sumatriptan, work by stimulating 5-HT1B/1D receptors in cerebral arteries, leading to vasoconstriction and reduced inflammation, thereby relieving migraine symptoms. A known adverse effect of triptans is chest tightness or pressure, which can mimic angina. This is due to the vasoconstrictive effects of the drug, which can affect coronary arteries. However, serious cardiac events are rare. Other common side effects of triptans include tingling, flushing, and dizziness.

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