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Reed Sternberg Cell 1

Reed-Sternberg cell


Vignette: A 26-year-old woman presents to her physician with a complaint of low-grade fever, fatigue, and unintentional weight loss over the past few months. On examination, a mass is palpated in the right upper quadrant of her abdomen. A biopsy of the mass is performed and the histopathology report states that it is a case of Hodgkin's lymphoma. The report further mentions the presence of a characteristic cell type with multiple, lobulated nuclei and prominent nucleoli. This cell is also known to contain abundant endoplasmic reticulum. What is the name of this cell?


A. Reed-Sternberg cell

B. Heinz body

C. Russell body

D. Aschoff body

E. Reed cell


A. Reed-Sternberg cell


The Reed-Sternberg cell is the characteristic cell of Hodgkin's lymphoma, a type of lymphoma that originates from white blood cells. These cells are large and often have multiple, lobulated nuclei with prominent nucleoli that give them an "owl's eye" appearance. The Reed-Sternberg cell is thought to derive from B lymphocytes and is known to contain abundant endoplasmic reticulum, which is necessary for the production and secretion of proteins involved in immune signaling. None of the other choices listed are associated with Hodgkin's lymphoma. Heinz bodies are seen in conditions with oxidative stress on red blood cells (such as G6PD deficiency), Russell bodies are seen in plasma cells usually in chronic inflammatory conditions, and Aschoff bodies are seen in rheumatic heart disease. The Reed cell is a non-existent term and is a distractor in this case.


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