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Anatomy Of The Large Intestine

Discover the fascinating intricacies and functions of the large intestine, unraveling its vital role in digestion and absorption, as we delve into the comprehensive anatomy of this essential organ.

Anatomy of the Large Intestine

This guide aims to provide a comprehensive understanding of the anatomy of the large intestine as it pertains to the United States Medical Licensing Examination (USMLE).


The large intestine, also known as the colon, is a vital part of the digestive system. It is responsible for the absorption of water, electrolytes, and vitamins, as well as the formation and elimination of feces. A thorough knowledge of the anatomy of the large intestine is essential for medical professionals, including those preparing for the USMLE.


The large intestine is approximately 5 feet long and consists of several distinct regions:

  1. Cecum: Located in the right lower quadrant of the abdomen, the cecum is a pouch-like structure that connects the small intestine to the large intestine. It houses the vermiform appendix, a small finger-like projection.

  2. Ascending Colon: The ascending colon extends superiorly from the cecum along the right side of the abdomen, reaching the hepatic flexure near the liver.

  3. Transverse Colon: The transverse colon crosses the abdomen horizontally, passing in front of the liver and stomach. It is connected to the ascending colon by the hepatic flexure and to the descending colon by the splenic flexure.

  4. Descending Colon: The descending colon descends vertically along the left side of the abdomen, starting from the splenic flexure.

  5. Sigmoid Colon: The sigmoid colon is an S-shaped segment located in the lower abdomen. It connects the descending colon to the rectum.

  6. Rectum: The rectum is the final part of the large intestine, connecting the sigmoid colon to the anus. It stores feces until elimination.

Blood Supply

The arterial blood supply to the large intestine is primarily derived from the superior mesenteric artery (SMA) and the inferior mesenteric artery (IMA).

  1. Superior Mesenteric Artery (SMA): This artery supplies blood to the cecum, ascending colon, transverse colon, and the proximal two-thirds of the transverse colon.

  2. Inferior Mesenteric Artery (IMA): The IMA supplies blood to the distal one-third of the transverse colon, descending colon, sigmoid colon, and rectum.

Nerve Supply

The large intestine receives innervation from the autonomic nervous system, specifically the sympathetic and parasympathetic divisions.

  1. Sympathetic Nerve Supply: Sympathetic nerve fibers originate from the thoracolumbar region (T10-L2) of the spinal cord. The primary sympathetic innervation of the large intestine is through the superior mesenteric plexus and the inferior mesenteric plexus.

  2. Parasympathetic Nerve Supply: Parasympathetic fibers originate from the craniosacral region (vagus nerve and sacral parasympathetic fibers). The parasympathetic innervation of the large intestine is primarily through the vagus nerve and the pelvic splanchnic nerves.


The histological composition of the large intestine includes several distinct layers:

  1. Mucosa: The innermost layer that lines the lumen of the large intestine. It contains simple columnar epithelium with goblet cells that secrete mucus.

  2. Submucosa: A connective tissue layer containing blood vessels, lymphatics, and submucosal glands.

  3. Muscularis Externa: Consists of two layers of smooth muscle, the inner circular and the outer longitudinal layer, which aid in peristalsis.

  4. Serosa: The outermost layer of the large intestine, composed of a thin layer of connective tissue covered by mesothelium.

Clinical Significance

Understanding the anatomy of the large intestine is crucial in diagnosing and treating various conditions such as colorectal cancer, diverticulitis, and inflammatory bowel disease. It also plays a significant role in surgical procedures such as colectomy and colostomy.


A thorough understanding of the anatomy of the large intestine is fundamental for medical professionals preparing for the USMLE. This guide has provided an overview of the structure, blood and nerve supply, histology, and clinical significance of the large intestine. Continuous study and practical application of this knowledge will ensure success in the assessment and clinical practice.

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