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Corpus Luteum

Discover the fascinating role of the corpus luteum in reproductive health and the surprising ways it impacts fertility and menstrual cycles.

USMLE Guide: Corpus Luteum


The Corpus Luteum is a temporary endocrine structure that develops in the ovaries after ovulation. It plays a crucial role in the female reproductive system, secreting hormones essential for conception and early pregnancy. This USMLE guide will provide an overview of the Corpus Luteum, its functions, regulation, and clinical significance.


The Corpus Luteum is derived from the follicle that releases the egg during ovulation. After ovulation, the remaining follicular cells in the ovary undergo structural and functional changes to form the Corpus Luteum. It typically appears as a yellowish structure within the ovary.


The primary function of the Corpus Luteum is to produce progesterone, a hormone essential for preparing the endometrium for implantation and maintaining early pregnancy. Progesterone inhibits uterine contractions, supports the development of blood vessels in the endometrium, and promotes the secretion of nutrients necessary for the embryo's growth.

Additionally, the Corpus Luteum secretes small amounts of estrogen, androgens, and inhibin. Estrogen helps maintain the endometrium, while androgens and inhibin support follicular development and regulate the menstrual cycle.


The Corpus Luteum is regulated by a complex interplay of hormones and feedback mechanisms. After ovulation, the pituitary gland releases luteinizing hormone (LH), which stimulates the transformation of the follicle into the Corpus Luteum. LH also triggers the production of progesterone by the Corpus Luteum.

If fertilization and implantation occur, the developing embryo releases human chorionic gonadotropin (hCG), which maintains the Corpus Luteum's function. hCG acts similarly to LH and ensures the continued production of progesterone until the placenta can take over hormone production.

If fertilization does not occur, the Corpus Luteum undergoes regression and transforms into the Corpus Albicans, a fibrous scar tissue.

Clinical Significance

Understanding the Corpus Luteum is crucial in various clinical scenarios:

  1. Luteal Phase Defect: Insufficient progesterone production by the Corpus Luteum can lead to a luteal phase defect, potentially causing infertility or early miscarriage. This condition may be treated with progesterone supplementation.

  2. Ectopic Pregnancy: In an ectopic pregnancy, the fertilized egg implants outside the uterus, typically in the fallopian tube. In this scenario, the Corpus Luteum continues to produce progesterone, leading to a positive pregnancy test despite the abnormal implantation. Clinicians should consider this possibility in cases of abdominal pain and positive pregnancy tests with an empty uterus.

  3. Ovarian Cysts: Corpus Luteum cysts may develop if the Corpus Luteum fails to regress. These cysts are usually benign and self-resolving but can cause pain or complications such as ovarian torsion or rupture.

  4. Oral Contraceptives: Combination oral contraceptives inhibit ovulation by suppressing the secretion of LH and FSH, preventing the formation of the Corpus Luteum. This mechanism helps prevent pregnancy.


The Corpus Luteum is a vital structure in the female reproductive system, responsible for progesterone production and supporting early pregnancy. Understanding its function, regulation, and clinical significance is crucial for medical professionals, particularly when managing infertility, ectopic pregnancies, ovarian cysts, and prescribing oral contraceptives.

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